RapamycinFungusV1, Main, Exploration, bibRecord, 001791

Coordinate regulation of multiple and distinct biosynthetic pathways by TOR and PKA kinases in S. cerevisiae.

Identifieur interne : 001791 ( Main/Exploration ); précédent : 001790; suivant : 001792

Coordinate regulation of multiple and distinct biosynthetic pathways by TOR and PKA kinases in S. cerevisiae.

Auteurs : Jenny C-Y Chen [États-Unis] ; Ted Powers

Source :

Current genetics [ 0172-8083 ] ; 2006.

RBID : pubmed:16397762

Descripteurs français

KwdFr :
- Cyclic AMP-Dependent Protein Kinases (MeSH), Lysine (biosynthèse), Lysine (génétique), Protein-Serine-Threonine Kinases (génétique), Protein-Serine-Threonine Kinases (physiologie), Protéines de Saccharomyces cerevisiae (génétique), Protéines de Saccharomyces cerevisiae (physiologie), Régulation de l'expression des gènes fongiques (MeSH), Saccharomyces cerevisiae (enzymologie), Saccharomyces cerevisiae (génétique), Séquençage par oligonucléotides en batterie (MeSH), Transduction du signal (MeSH).
MESH :
- biosynthèse : Lysine.
- enzymologie : Saccharomyces cerevisiae.
- génétique : Lysine, Protein-Serine-Threonine Kinases, Protéines de Saccharomyces cerevisiae, Saccharomyces cerevisiae.
- physiologie : Protein-Serine-Threonine Kinases, Protéines de Saccharomyces cerevisiae.
- Cyclic AMP-Dependent Protein Kinases, Régulation de l'expression des gènes fongiques, Séquençage par oligonucléotides en batterie, Transduction du signal.

English descriptors

KwdEn :
- Cyclic AMP-Dependent Protein Kinases (MeSH), Gene Expression Regulation, Fungal (MeSH), Lysine (biosynthesis), Lysine (genetics), Oligonucleotide Array Sequence Analysis (MeSH), Protein-Serine-Threonine Kinases (genetics), Protein-Serine-Threonine Kinases (physiology), Saccharomyces cerevisiae (enzymology), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae Proteins (genetics), Saccharomyces cerevisiae Proteins (physiology), Signal Transduction (MeSH).
MESH :
- chemical , biosynthesis : Lysine.
- chemical , genetics : Lysine, Protein-Serine-Threonine Kinases, Saccharomyces cerevisiae Proteins.
- chemical , physiology : Protein-Serine-Threonine Kinases, Saccharomyces cerevisiae Proteins.
- chemical : Cyclic AMP-Dependent Protein Kinases.
- enzymology : Saccharomyces cerevisiae.
- genetics : Saccharomyces cerevisiae.
- Gene Expression Regulation, Fungal, Oligonucleotide Array Sequence Analysis, Signal Transduction.

Abstract

The target of rapamycin (TOR) signaling pathway is an essential regulator of cell growth in eukaryotic cells. In Saccharomyces cerevisiae, TOR controls the expression of many genes involved in a wide array of distinct nutrient-responsive metabolic pathways. By exploring the TOR pathway under different growth conditions, we have identified novel TOR-regulated genes, including genes required for branched-chain amino acid biosynthesis as well as lysine biosynthesis (LYS genes). We show that TOR-dependent control of LYS gene expression occurs independently from previously identified LYS gene regulators and is instead coupled to cAMP-regulated protein kinase A (PKA). Additional genome-wide expression analyses reveal that TOR and PKA coregulate LYS gene expression in a pattern that is remarkably similar to genes within the ribosomal protein and "Ribi" regulon genes required for ribosome biogenesis. Moreover, this pattern of coregulation is distinct from other clusters of TOR/PKA coregulated genes, which includes genes involved in fermentation as well as aerobic respiration, suggesting that control of gene expression by TOR and PKA involves multiple modes of crosstalk. Our results underscore how multiple signaling pathways, general growth conditions, as well as the availability of specific nutrients contribute to the maintenance of appropriate patterns of gene activity in yeast.

DOI: 10.1007/s00294-005-0055-9
PubMed: 16397762

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">The target of rapamycin (TOR) signaling pathway is an essential regulator of cell growth in eukaryotic cells. In Saccharomyces cerevisiae, TOR controls the expression of many genes involved in a wide array of distinct nutrient-responsive metabolic pathways. By exploring the TOR pathway under different growth conditions, we have identified novel TOR-regulated genes, including genes required for branched-chain amino acid biosynthesis as well as lysine biosynthesis (LYS genes). We show that TOR-dependent control of LYS gene expression occurs independently from previously identified LYS gene regulators and is instead coupled to cAMP-regulated protein kinase A (PKA). Additional genome-wide expression analyses reveal that TOR and PKA coregulate LYS gene expression in a pattern that is remarkably similar to genes within the ribosomal protein and "Ribi" regulon genes required for ribosome biogenesis. Moreover, this pattern of coregulation is distinct from other clusters of TOR/PKA coregulated genes, which includes genes involved in fermentation as well as aerobic respiration, suggesting that control of gene expression by TOR and PKA involves multiple modes of crosstalk. Our results underscore how multiple signaling pathways, general growth conditions, as well as the availability of specific nutrients contribute to the maintenance of appropriate patterns of gene activity in yeast.</div>
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<Abstract><AbstractText>The target of rapamycin (TOR) signaling pathway is an essential regulator of cell growth in eukaryotic cells. In Saccharomyces cerevisiae, TOR controls the expression of many genes involved in a wide array of distinct nutrient-responsive metabolic pathways. By exploring the TOR pathway under different growth conditions, we have identified novel TOR-regulated genes, including genes required for branched-chain amino acid biosynthesis as well as lysine biosynthesis (LYS genes). We show that TOR-dependent control of LYS gene expression occurs independently from previously identified LYS gene regulators and is instead coupled to cAMP-regulated protein kinase A (PKA). Additional genome-wide expression analyses reveal that TOR and PKA coregulate LYS gene expression in a pattern that is remarkably similar to genes within the ribosomal protein and "Ribi" regulon genes required for ribosome biogenesis. Moreover, this pattern of coregulation is distinct from other clusters of TOR/PKA coregulated genes, which includes genes involved in fermentation as well as aerobic respiration, suggesting that control of gene expression by TOR and PKA involves multiple modes of crosstalk. Our results underscore how multiple signaling pathways, general growth conditions, as well as the availability of specific nutrients contribute to the maintenance of appropriate patterns of gene activity in yeast.</AbstractText>
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	Serveur d'exploration sur la rapamycine et les champignons
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Coordinate regulation of multiple and distinct biosynthetic pathways by TOR and PKA kinases in S. cerevisiae.

Coordinate regulation of multiple and distinct biosynthetic pathways by TOR and PKA kinases in S. cerevisiae.

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